Effects of extract from Cornus officinalis on nitric oxide and NF-kappaB in cortex of cerebral infarction rat model / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1667-1670, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-287350
ABSTRACT
<p><b>OBJECTIVE</b>To observe the change of nitric oxide (NO) and expression of nuclear factor-kappa B (NF-kappaB) in the cortex of cerebral infarction rat induced by photochemical reaction, and study the effect of extract from Cornus officinalis (whose main ingredient is iridoid glycoside) in the course of disease.</p><p><b>METHOD</b>After rats were fed with experimental drugs for 7 days, the model of cerebral infarction was induced. Spectrophotography and immunohistochemistry were used to detect the change of the content of NO, NOS and the expression of NF-kappaB in the cortex.</p><p><b>RESULT</b>Compared with control group, distinct infarction was visible in the model group, and the content of NO, the activity of NOS and the positive cell number of NF-kappaB were increased obviously. Compared with model group, the extract of C. officeinalis decreased the area of infarction, the content of NO, the activity of NOS and the positive cell number of NF-kappaB.</p><p><b>CONCLUSION</b>The iridoid glycoside of C. officinalis may have therapeutical effect on cerebral infarction through regulating the content of NO and NF-kappaB.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Farmacología
/
Plantas Medicinales
/
Medicamentos Herbarios Chinos
/
Distribución Aleatoria
/
Corteza Cerebral
/
Infarto Cerebral
/
Química
/
FN-kappa B
/
Ratas Sprague-Dawley
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2005
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS