Your browser doesn't support javascript.
loading
Association study on the mitochondrial genome region np16181-16193 variation with type 2 diabetes mellitus / 中华医学遗传学杂志
Chinese Journal of Medical Genetics ; (6): 340-344, 2009.
Artículo en Chino | WPRIM | ID: wpr-287394
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of the mitochondrial DNA region np16181-16193 variations with type 2 diabetes mellitus (T2DM).</p><p><b>METHODS</b>Blood samples of 199 unrelated T2DM patients and 205 normal controls were collected to detect the mitochondrial DNA region np16181-16193 variations by PCR and sequencing, and to analyze the association of the variations with the major clinical symptoms.</p><p><b>RESULTS</b>The mitochondrial DNA np16181-16193 region is a hypervariable area, with several polymorphisms. Four types of np16181-16193 region variations were found only in T2DM. The 1-hour postprandial blood glucose (P1BG) in the T2DM individuals with np16181-16193 region variations was significantly higher than those without variations (P<0.05), while there was no significant difference in other biochemical parameters (P>0.05).</p><p><b>CONCLUSION</b>The mitochondrial DNA np16181-16193 variations could not be regarded as a risk factor for T2DM.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: ADN Mitocondrial / Análisis Mutacional de ADN / Análisis de Secuencia de ADN / Predisposición Genética a la Enfermedad / Regiones Determinantes de Complementariedad / Diabetes Mellitus Tipo 2 / Genoma Mitocondrial / Genética Tipo de estudio: Factores de riesgo Límite: Adulto / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Medical Genetics Año: 2009 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: ADN Mitocondrial / Análisis Mutacional de ADN / Análisis de Secuencia de ADN / Predisposición Genética a la Enfermedad / Regiones Determinantes de Complementariedad / Diabetes Mellitus Tipo 2 / Genoma Mitocondrial / Genética Tipo de estudio: Factores de riesgo Límite: Adulto / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Medical Genetics Año: 2009 Tipo del documento: Artículo