Terpenoids and sterols from Ricinus communis and their activities against diabetes / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 448-452, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-287567
ABSTRACT
Seven terpenoids and three sterols were isolated from the methanol extracts of the aerial parts of Ricinus communis by chromatography methods and their structures were identified by spectra analysis as ficusic acid( 1), phytol(2), callyspinol(3) , lupeol(4), 30-norlupan-3beta-ol-20-one(5) , lup-20(29)-en-3beta,15alpha-diol(6) , acetylaleuritolic acid( 7), stigmast4-en-3-one(8) , stig-mast-4-en-6beta-ol-3-one(9) , and stigmast4-en-3,6-dione(10). Compounds 1-3 and 5-10 were obtained from this species for the first time and 5 and 6 showed significant inhibitive activity and good selectivity against 11beta-HSD of mouse and human in vitro. [Key words] Ricinus communis; terpenoids; sterols; 11beta-HSD
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Ricinus
/
Esteroles
/
Terpenos
/
Química
/
Concentración 50 Inhibidora
/
11-beta-Hidroxiesteroide Deshidrogenasa de Tipo 1
/
11-beta-Hidroxiesteroide Deshidrogenasa de Tipo 2
/
Usos Terapéuticos
/
Diabetes Mellitus
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2014
Tipo del documento:
Artículo
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