In vivo/in vitro evaluation of Kangfuxin colon targeting capsules / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the release in fixed position of pH-dependent and enzyme-dependent Kangfuxin colon targeting capsules in vivo and in vitro.</p><p><b>METHOD</b>The dissolution was tested in vitro and X-ray radiography was used for the evaluation in vivo.</p><p><b>RESULT</b>After two hours pH-dependent colon targeting in man-made colon fluid, medicine release in fixed position on the whole, colon loc-release. Add enzyme into man-made colon, when enzyme-dependent colon targeting in it, then medicine release quickly, mainly release in fixed position; The conveying time in vivo of pH-dependent and enzyme-dependent capsules have big individuality difference. In the experiment, disintegration is stabilize among individuales, between 2.0-3.5 hours.</p><p><b>CONCLUSION</b>Kangfuxin colon targeting capsules of two principles all release in fixed position to achieve the goal.</p>