Effects of volatie oil of Schizonepeta tenuifolia Briq herb and Saposhnikovia divaricata Schischke root on proinflammatory cytokine expression and regulation / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1777-1779, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-287896
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of volatie oil of Schizonepeta tenuifolia Briq herb and Saposhnikovia divaricata Schischke root (OSS) on proinflammatory cytokine expression and regulation in rats.</p><p><b>METHOD</b>OA and LPS were injected intravenously to rats to develop acute lung injury (ALI). The rats were treated with OSS (45.19 microL kg(-1)). The pathological sections of lung tissue were prepared and observed in acute lung injury rats. The expression of nuclear factor-kappa B p65 (NF-kappaB p65), intercellar adhesion molecule CD54, and NF-kappaB p65 mRNA were determined in lung cells.</p><p><b>RESULT</b>volatie oil of Schizonepeta tenuifolia Briq herb and Saposhnikovia divaricata Schischke root significantly inhibited the expression of CD54, the activation of NF-kappaB p65, and the transcription of NF-kappaB p65 mRNA.</p><p><b>CONCLUSION</b>OSS can reduce the expression of CD54 and NF-kappaB p65 protein synthesis, which may be its anti-inflammatory molecular mechanisms.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Plantas Medicinales
/
Síndrome de Dificultad Respiratoria
/
Aceites de Plantas
/
ARN Mensajero
/
Aceites Volátiles
/
Inmunohistoquímica
/
Distribución Aleatoria
/
Química
/
Regulación de la Expresión Génica
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2007
Tipo del documento:
Artículo
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