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Clinical observation on the prevention and treatment of perioperative delayed cerebrovasospasm in patients with aneurysmal subarachnoid hemorrhage by the comprehensive protocol of integrative medicine / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine ; (12): 1345-1349, 2012.
Artículo en Chino | WPRIM | ID: wpr-288458
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the efficacy and safety of the comprehensive protocol of integrative medicine in preventing and treating perioperative delayed cerebrovasospasm (DCVS) in patients with aneurysmal subarachnoid hemorrhage (aSAH).</p><p><b>METHODS</b>Using a prospective randomized controlled trial design, 63 aSAH inpatients were assigned to the treatment group (31 cases, 24 treated by intervention treatment and 7 by craniotomy) and the control group (32 cases, 26 treated by intervention treatment and 6 by craniotomy). All patients were treated with basic therapy and nimodipine. Those in the treatment group additionally took naomai jiejing decoction No. 1 and No. 2. The incidence and the mortality of DCVS, re-bleeding, hydrocephalus were compared on the 180th day. The middle cerebral artery mean flow velocity (Vm), PI value, linde-gard index on day 1, 3, 7, and 14 were compared. The Chinese medicine syndrome score, NIHSS, and revised Rankin questionnaire on day 1, 14, and 180 were compared.</p><p><b>RESULTS</b>The DCVS occurred in 9 cases (29. 0%) of the treatment group and 17 patients (53.1%) of the control group, showing statistical difference (P < 0.05). The occurrence of re-hemorrhage was obviously lower in the treatment than in the control group (3.2% vs. 6.2%), showing statistical difference (P < 0. 05). There was no statistical difference in the mortality (6.4% vs. 9.4%) or the occurrence of hydrocephalus (29.0% vs 25.0%, P > 0.05). The Vm, PI, and linde-gard index on day 7, the Vm and linde-gard index on day 14 were obviously lower in the treatment group than in the control group (P < 0.05). The Chinese medicine syndrome score and NIHSS on day 14 and 180 were lower in the treatment group than in the control group, showing statistical difference (P < 0.05).</p><p><b>CONCLUSION</b>The comprehensive protocol of integrative medicine could reduce the incidence of aSAH patients' DCVS, the Chinese medicine syndrome score and NIHSS, and improve their clinical symptoms.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Hemorragia Subaracnoidea / Terapéutica / Medicamentos Herbarios Chinos / Aneurisma Intracraneal / Trastornos Cerebrovasculares / Estudios Prospectivos / Resultado del Tratamiento / Usos Terapéuticos / Medicina Integrativa / Periodo Intraoperatorio Tipo de estudio: Ensayo Clínico Controlado / Estudio diagnóstico / Guía de Práctica Clínica / Estudio observacional Límite: Adolescente / Adulto / Anciano / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Integrated Traditional and Western Medicine Año: 2012 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Hemorragia Subaracnoidea / Terapéutica / Medicamentos Herbarios Chinos / Aneurisma Intracraneal / Trastornos Cerebrovasculares / Estudios Prospectivos / Resultado del Tratamiento / Usos Terapéuticos / Medicina Integrativa / Periodo Intraoperatorio Tipo de estudio: Ensayo Clínico Controlado / Estudio diagnóstico / Guía de Práctica Clínica / Estudio observacional Límite: Adolescente / Adulto / Anciano / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Integrated Traditional and Western Medicine Año: 2012 Tipo del documento: Artículo