The therapeutic effects of fluid resuscitation in severe sepsis and septic shock / 中华外科杂志
Chinese Journal of Surgery
;
(12): 1336-1338, 2006.
Artículo
en Chino
| WPRIM
| ID: wpr-288594
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the therapeutic effect of fluid resuscitation on severe sepsis and septic shock.</p><p><b>METHODS</b>Twenty patients with severe sepsis and septic shock were given fluid resuscitation and got the following parameters in the ranges as follow central venous pressure (CVP) 8 - 12 mm Hg (for ventilation patient 12 - 15 mm Hg), mean artery pressure (MAP) 65 - 90 mm Hg, mixed venous oxygen saturation (SmvO(2)) > 70%. Hemodynamics, tissue perfusion and vascular endothelial cell function were measured and compared before and after fluid resuscitation.</p><p><b>RESULTS</b>Pulmonary arterial wedge pressure (PAWP), cardiac index (CI), left ventricular stroke work index (LVSWI) and systemic vascular resistance index (SVRI) increased significantly after reached the goal of fluid resuscitation (P < 0.01) whereas pulmonary vascular resistance index (PVRI), lactate level in arterial blood and gastric-to-arterial carbon dioxide partial pressure gap (Pg-aCO(2)) decreased significantly (P < 0.01), and the serum levels of endothelin (ET) and von Willebrand factor (vWF) were also decreased significantly after fluid resuscitation (P < 0.05).</p><p><b>CONCLUSIONS</b>Early goal-directed fluid resuscitation can improve hemodynamics, tissue perfusion and alleviate vascular endothelial cell injury in patients with severe sepsis and septic shock, it is an effective therapy for these patients.</p>
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Resucitación
/
Choque Séptico
/
Terapéutica
/
Sangre
/
Análisis de los Gases de la Sangre
/
Presión Sanguínea
/
Resultado del Tratamiento
/
Sepsis
/
Fluidoterapia
/
Métodos
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Surgery
Año:
2006
Tipo del documento:
Artículo
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