Study about target-network of anti-cerebral infarction neuropathy based on theory of neurovascular unit and network pharmacology / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 138-141, 2012.
Article
en Zh
| WPRIM
| ID: wpr-288684
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>Potention drug-targets on anti-neuropathy of stroke were summarized, and it will provide materials for developing innovation components traditional Chinese medicine on anti-cerebral infarction neuropathy.</p><p><b>METHOD</b>This article had done a series of researching work about neurovascular unit which includes three kinds of cells: neuron, gliacyte,brain microvascular endothelial cell, then signal mechanism of cell death or apoptosis of each section of stroke neuropathy was analysised by the historical documents.</p><p><b>RESULT</b>There are five important pathways: inflammatory factor-MMPs pathway- Caspases, Ca2+ -mitochondrial pathway-Caspases, Ca2+ -Phospholipase-PI-3K/AK pathway, Ca2+ -radical-MAPK pathway, Ca2+ -NO-protease pathway, among all the nodes, Caspases, Ca2+, NO were the most important ones.</p><p><b>CONCLUSION</b>Developing the multi-mechanism and multilevel of traditional chinese medicine under the guidance of the theories of network pharmacology and neurovascular unit will play an important role in studying the key links of signal-network of stroke neuropathy.</p>
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Farmacología
/
Polineuropatías
/
Transducción de Señal
/
Infarto Cerebral
/
Calcio
/
Sistemas de Liberación de Medicamentos
/
Fosfatidilinositol 3-Quinasas
/
Caspasas
/
Metaloproteinasas de la Matriz
/
Sistema de Señalización de MAP Quinasas
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Año:
2012
Tipo del documento:
Article