Comparison of effects of badu shengji san on rats with different injured skins / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To compare the effects of Badu Shengji San (BDSJS) on rats with different injured skins.</p><p><b>METHOD</b>The injured and ulcerous skin rat model was established to observe the renal injury induced by BDSJS, a mercury-containing external preparation of Chinese medicine, with urinary N-acetyl-beta-D-glucosaminidase (NAG) and retinol binding protein (RBP) as indicators of renal toxicity.</p><p><b>RESULT</b>Compared to injured skin rats with the same dose, both of high and low-dose ulcerous skin groups showed obvious increase in urinary RBP and kidney coefficients, significant pathomorphological changes in renal tubules and notable epithelial cytopathic effects. In terms of NAG, the high-dose ulcerous skin group saw no significant increase, but the low-dose group recorded sharp rise.</p><p><b>CONCLUSION</b>The renal toxicity induced by BDSJS in ulcerous skin rats was more toxic than that in injured skin ones.</p>