Correlation between brain-derived neurotrophic factor expression in the nerve system and erectile dysfunction in diabetic rats / 中华男科学杂志
National Journal of Andrology
;
(12): 1066-1071, 2006.
Artículo
en Chino
| WPRIM
| ID: wpr-289078
ABSTRACT
<p><b>OBJECTIVE</b>To observe the correlation between brain-derived neurotrophic factor (BDNF) expression in the nerve system of diabetes mellitus (DM) rats and diabetic erectile dysfunction (ED).</p><p><b>METHODS</b>DM rats were induced by injecting streptozotocin and erectile function test was done by injecting apomorphine (APO) at 1 month, 2 months, 3 months and 4 months. Then the brain, lumbosacral spinal cord, thoracic and lumbar sympathetic trunks, penis and prostate were taken from the diabetic and normal rats of the same age. The BDNF positive neurons and nerve fibers were shown by immunohistochemistry or fluorescence immunohistochemistry. The number and the grey density of BDNF positive cells and fibers were detected by image analysis.</p><p><b>RESULTS</b>Compared with the control group, the erection frequency of the DM rats decreased at 2 months (P <0. 05) , and significantly at 3 and 4 months (P > 0.01) , and the BDNF positive neurons and nerve fibers in the cerebral cortex, lumbosacral spinal cord, thoracic and lumbar sympathetic trunks, penis and prostate of 1-month DM rats were reduced (P <0. 05). As time went on, BDNF declined progressively.</p><p><b>CONCLUSION</b>BDNF decreases in the central and peripheral nerve system in the early stage of diabetes mellitus, wich is closely correlated with diabetic ED.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Ratas Sprague-Dawley
/
Factor Neurotrófico Derivado del Encéfalo
/
Diabetes Mellitus Experimental
/
Disfunción Eréctil
/
Metabolismo
/
Tejido Nervioso
Límite:
Animales
Idioma:
Chino
Revista:
National Journal of Andrology
Año:
2006
Tipo del documento:
Artículo
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