The influence of N-acetyl-L-cysteine on pulmonary injury and oxygen stress after smoke inhalation injury / 中华烧伤杂志
Chinese Journal of Burns
;
(6): 152-154, 2002.
Artículo
en Chino
| WPRIM
| ID: wpr-289222
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the influence of N-acetyl-L-cysteine (NAC) on pulmonary injury and oxygen stress caused by smoke inhalation injury.</p><p><b>METHODS</b>Rats inflicted with smoke inhalation injury were employed as the model. WBC in BALF (bronchoalveolar lavage fluid), MPO (myeloperoxidase) activity, hydrogen peroxide (H(2)O(2)) content, GSH (glutathione) content and total antioxidant (TAO) capacity in pulmonary tissue were determined.</p><p><b>RESULTS</b>Postinjury WBC in BALF, MPO activity in pulmonary tissue and H(2)O(2) content decreased obviously after NAC treatment. But the pulmonary tissue contents of GSH and ATO increased evidently after the treatment with NAC.</p><p><b>CONCLUSION</b>NAC treatment could ameliorate pulmonary oxygen stress after smoke inhalation injury. AS a result, the pulmonary antioxidant capacity was improved.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Farmacología
/
Acetilcisteína
/
Líquido del Lavado Bronquioalveolar
/
Lesión por Inhalación de Humo
/
Depuradores de Radicales Libres
/
Ratas Wistar
/
Peroxidasa
/
Estrés Oxidativo
/
Modelos Animales de Enfermedad
Límite:
Animales
Idioma:
Chino
Revista:
Chinese Journal of Burns
Año:
2002
Tipo del documento:
Artículo
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