Sedative and anticonvulsant effect of jujuboside A / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 103-106, 2002.
Artículo
en Chino
| WPRIM
| ID: wpr-289346
ABSTRACT
OBJECTIVE:
To study the sedative effects of Jujuboside A (JuA) on the Central Nervous System of mice.METHODS:
Using a novel jiggle-cage test, we compared the sedative effect of JuA with that of Diazepam (DZP) both with a single and cumulative dose of JuA. We also assessed the anticonvulsant effect of JuA on pentylenetetrazol (PTZ)-induced seizures in mice.RESULTS:
JuA significantly decreased total activity intensity and increased the quiet state time of mice. The sedative effects of JuA were more stable and more lasting than that of DZP. However, JuA failed to resist and delay the induced seizure activity in mice.CONCLUSION:
Though JuA has sedative effects on mice CNS, it has no anticonvulsant effect on PTZ-induced seizures.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Journal of Zhejiang University. Medical sciences
Año:
2002
Tipo del documento:
Artículo
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