Preparation and in vitro release characteristics of curcumin in nanosuspensions / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 132-135, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-289414
ABSTRACT
<p><b>OBJECTIVE</b>To prepare curcumin albumin nanosuspensions and study its release characteristics in vitro.</p><p><b>METHOD</b>Curcumin albumin nanosuspensions were prepared by solvent evaporation method. The nanosuspensions were characterized in terms of morphology, size, encapsulation efficiency and in vitro drug release.</p><p><b>RESULT</b>The mean size of albumin nanosuspensions before lyophilization was 245.2 nm and 240.3 nm after reconstitution. The distribution of particle size was uniform. The encapsulation efficiency was (42.39 +/- 0.91)%. In vitro release study revealed that the 72 h accumulative release percentage reached 96%.</p><p><b>CONCLUSION</b>The method described to prepare curcumin albumin nanosuspensions is simple. It might be a novel vehicle potentially for nanoparticle drug delivery system of curcumin.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Tamaño de la Partícula
/
Medicamentos Herbarios Chinos
/
Cinética
/
Química
/
Curcumina
/
Curcuma
/
Composición de Medicamentos
/
Nanopartículas
/
Métodos
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2011
Tipo del documento:
Artículo
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