Effects of r-hGH replacement therapy on glucose and lipid metabolism and thyroid function in children with idiopathic short stature / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 1236-1240, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-289495
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of recombinant human growth hormone (r-hGH) replacement therapy on glucose and lipid metabolism and thyroid function in children with idiopathic short stature (ISS).</p><p><b>METHODS</b>Forty-seven ISS children with a mean age of 10±3 years treated between January 2009 and January 2013 were enrolled. All children underwent r-hGH replacement therapy for 3-24 months and were followed up once every 3 months. Fasting blood glucose (FBG), insulin (INS), blood lipids and thyroid function were measured before treatment and after 0-1 and 1-2 years of treatment.</p><p><b>RESULTS</b>After treatment with r-hGH, there were no significant changes in FBG, INS, insulin sensitivity index (ISI), and FBG/INS ratio (FGIR), but the FGIR showed a declining trend. The percentage of patients with FGIR<7 (a marker of insulin resistance) was 13% before treatment compared to 18% 1-2 years after treatment. The atherosclerosis index decreased after r-hGH treatment, but there were no significant changes in total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and BMI. Furthermore, no significant change in thyroid function was observed after r-hGH therapy.</p><p><b>CONCLUSIONS</b>r-hGH therapy can improve lipid metabolism, without significant impacts on thyroid function, FBG and INS. It seems to be a safe and reliable therapy for children with ISS. However, this therapy possibly reduces insulin sensitivity.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Glándula Tiroides
/
Sangre
/
Glucemia
/
Hormona de Crecimiento Humana
/
Terapia de Reemplazo de Hormonas
/
Usos Terapéuticos
/
Quimioterapia
/
Metabolismo de los Lípidos
/
Glucosa
/
Trastornos del Crecimiento
Límite:
Adolescente
/
Niño
/
Child, preschool
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Contemporary Pediatrics
Año:
2014
Tipo del documento:
Artículo
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