Efficacy of dual antiplatelet therapy combined with Naoxintong capsules see text following coronary microembolization induced by homologous microthrombi in rats / 中国结合医学杂志
Chinese journal of integrative medicine
;
(12): 917-924, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-289719
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effificacy of dual antiplatelet therapy combined with Naoxintong Capsule ([see text], NXTC) in a rat model of coronary microembolization (CME).</p><p><b>METHODS</b>A total of 95 rats were randomly divided into 6 groups control, sham-operation, CME model, NXTC, dual antiplatelet (clopidogrel and aspirin) intervention (DA), and NXTC combined with DA (NDA) groups. The complete data in 69 rats were obtained. The number of CME, myocardial apoptosis rate, bleeding time, clotting time, and adensosine diphosphate (ADP)-induced platelet aggregation were assessed.</p><p><b>RESULTS</b>Compared with the CME group, the number of CME and myocardial apoptosis rates were signifificantly decreased in the NXTC, DA, and NDA groups (P <0.01). Compared with other intervention groups, the number of CME and myocardial apoptosis rates were the least in the NDA group (P <0.01), and the incidence of surgical bleeding was the highest in the DA group (P <0.01). Compared with the CME group, ADP-induced maximum platelet aggregation rate was significantly inhibited in the NXTC, DA, and NDA groups (P <0.01), both bleeding time and clotting time were signifificantly increased in the NXTC, DA, and NDA groups (P <0.01), while the above parameters were the highest in the DA group (P <0.05).</p><p><b>CONCLUSION</b>The combination therapy of NXTC and DA enhanced the anti-CME effect of either therapy alone and reduced the risk of the DA therapy-associated bleeding, demonstrating an improved benefifit/ risk ratio in the rat model of CME.</p>
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Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Farmacología
/
Trombosis
/
Coagulación Sanguínea
/
Cápsulas
/
Medicamentos Herbarios Chinos
/
Inhibidores de Agregación Plaquetaria
/
Análisis de Supervivencia
/
Pérdida de Sangre Quirúrgica
/
Ratas Sprague-Dawley
Límite:
Animales
Idioma:
Inglés
Revista:
Chinese journal of integrative medicine
Año:
2011
Tipo del documento:
Artículo
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