Transient Receptor Potential Melastatin 2:an Ion Channel for Oxidative Stress Sensing / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 364-367, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-289854
ABSTRACT
Transient receptor potential (TRP) channel is a superfamily of cation channels located on the cell membrane. TRP channels are classified into seven subfamilies based on the amino acid sequence homology,and transient receptor potential melastatin 2(TRPM2) is the second member of the TRPM subfamily. More evidences have revealed the important roles of TRPM2 in physiological and pathological events such as release of insulin from pancreatic Β-cells,inflammatory cytokines production from cells,and oxidative stress-induced cell death. As a cellular sensor for oxidative stress channel,TRPM2 is activated by a variety of factors. TRPM2 is a potential therapeutic target for oxidative stress-related diseases.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
Citocinas
/
Muerte Celular
/
Estrés Oxidativo
/
Canales Catiónicos TRPM
/
Insulina
Límite:
Humanos
Idioma:
Inglés
Revista:
Acta Academiae Medicinae Sinicae
Año:
2016
Tipo del documento:
Artículo
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