Prognostic Superiority of Log Odds of Positive Lymph Nodes in Stage 3 Colorectal Cancer / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 294-299, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-289867
ABSTRACT
Objective To evaluate the prognostic value of the log odds of positive lymph nodes (LODDS) in stage 3 colorectal cancer (CRC) patients who have undergone curative resection. Methods We performed a retrospective review of 175 stage 3 CRC patients who underwent curative resection in Peking Union Medical College Hospital from 2005 to 2012. Patients were categorized respectively according to the AJCC/UICC N grade,the metastatic lymph node ratio (LNR),and the ratio of their LODDS. The relationship between the N grade,LNR,LODDS,and overall survival (OS) rates were assessed.Results The five-year disease-free survival (DFS) was significantly different among stage 3 CRC patients in different N grade (Χ(2)=33.1,P=0.000),LNR (Χ(2)=14.3,P=0.001),and LODDS (Χ(2)=14.9,P=0.001). Univariate analysis showed that TNM stage (Χ(2)=27.0,P=0.000),cancerous node(Χ(2)=3.6,P=0.040),N grade (Χ(2)=33.1,P=0.000),LNR (Χ(2)=14.3,P=0.001),and LODDS (Χ(2)=30.4,P=0.000) were related to OS. Multivariate analysis indicated that TNM stage (HR1.84,95%CI1.59~6.29,P=0.001) and LODDS classification (HR1.34,95%CI1.01~1.80,P=0.047) were independent prognostic factors for OS in stage 3 CRC patients. Conclusion LODDS is a good prognostic indicator in stage 3 CRC patients who have undergone curative resection.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Pronóstico
/
Neoplasias Colorrectales
/
Análisis Multivariante
/
Tasa de Supervivencia
/
Estudios Retrospectivos
/
Supervivencia sin Enfermedad
/
Diagnóstico
/
Ganglios Linfáticos
/
Metástasis Linfática
Tipo de estudio:
Estudio diagnóstico
/
Estudio observacional
/
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Acta Academiae Medicinae Sinicae
Año:
2016
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS