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Effect of FCGR3A Polymorphisms on Antibody-dependent Cetuximab-mediated Cytotoxicity in A549 Cells / 中国医学科学院学报
Acta Academiae Medicinae Sinicae ; (6): 645-649, 2015.
Artículo en Chino | WPRIM | ID: wpr-289931
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of FCGR3A polymorphisms on the antibody-dependent cell-mediated cytotoxicity (ADCC) activity induced by cetuximab against A549 cells.</p><p><b>METHODS</b>A549 cell line was used as target cells and NKTm cells as effector cells. FCGR3A polymorphisms were detected by direct sequencing. The ADCC activity mediated by cetuximab was assessed by CCK-8 assay.</p><p><b>RESULTS</b>Three genotypes of FCGR3A were detectedV/V,V/F,and F/F. The ADCC activity of NKTm cells with these three different genotypes mediated by cetuximab were significantly different (P=0.0015). NKTm cells with FCGR3A-158V/V genotypes had significantly higher ADCC activity than FCGR3A-V/F or F/F genotypes (P<0.01),whereas the ADCC activity between V/F and F/F genotype showed no statistical significance(P>0.05).</p><p><b>CONCLUSION</b>FCGR3A polymorphisms have an impact on ADCC activity mediated by cetuximab in NKTm cells.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Polimorfismo Genético / Receptores de IgG / Línea Celular Tumoral / Cetuximab / Genotipo / Citotoxicidad Celular Dependiente de Anticuerpos Límite: Humanos Idioma: Chino Revista: Acta Academiae Medicinae Sinicae Año: 2015 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Polimorfismo Genético / Receptores de IgG / Línea Celular Tumoral / Cetuximab / Genotipo / Citotoxicidad Celular Dependiente de Anticuerpos Límite: Humanos Idioma: Chino Revista: Acta Academiae Medicinae Sinicae Año: 2015 Tipo del documento: Artículo