Research Advances in NLRP3 Inflammasome-related Regulatory Mechanisms / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 618-622, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-289935
ABSTRACT
Inflammasome is one of the pattern recognition receptors whose activation directly relates to the maturity and secretion of proinflammatory cytokines interleukin (IL)-1Β and IL-18. Thus, it plays an important role in the humoral immunity. A growing number of studies have found that inflammasome has a close relationship with the pathogenesis of various diseases including atherosclerosis,diabetes, and gout. However,the activation of the inflammasome and its specific regulatory mechanisms remain not clear. This article reviews the possible regulatory mechanisms of the inflammasome NLRP3 in terms of oxidative stress, endoplasmic reticulum stress,and autophagy reaction.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Proteínas Portadoras
/
Interleucina-1beta
/
Inflamasomas
/
Proteína con Dominio Pirina 3 de la Familia NLR
/
Inflamación
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Acta Academiae Medicinae Sinicae
Año:
2015
Tipo del documento:
Artículo
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