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Relationship between quinone oxidoreductase1 gene ns-cSNP and genetic susceptibility of esophageal cancer / 中华预防医学杂志
Chinese Journal of Preventive Medicine ; (12): 324-327, 2006.
Artículo en Chino | WPRIM | ID: wpr-290266
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between quinone oxidoreductase1 (NQO1) gene nonsynonymous cSNP and the genetic susceptibility of esophageal cancer.</p><p><b>METHODS</b>Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and Allele-Specific PCR (AS-PCR) were employed to assess the polymorphism of NQO1 genes both in 106 patients with esophageal cancer and control subjects matched by age, gender and origin.</p><p><b>RESULTS</b>It was shown that no C/C genotype was found at 406 of NQO1. The allelic frequency of NQO1 609T was significantly higher in patients with esophageal cancer than in the control subjects (P < 0.005) and the individuals with 609T allelic genotype of NQO1 gene were at greater risk to develop esophageal cancer (OR = 4.76, 95% CI = 1.064 - 3.397). But Individuals with mutant allele of NQO1 465 genotype did not show the rising risk of esophageal cancer.</p><p><b>CONCLUSIONS</b>The NQO1 C609T polymorphisms should likely be associated with the genetic susceptibility of esophageal cancer.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias Esofágicas / China / NAD(P)H Deshidrogenasa (Quinona) / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Alelos / Etnología / Frecuencia de los Genes / Genética / Genotipo Límite: Humanos País/Región como asunto: Asia Idioma: Chino Revista: Chinese Journal of Preventive Medicine Año: 2006 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias Esofágicas / China / NAD(P)H Deshidrogenasa (Quinona) / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Alelos / Etnología / Frecuencia de los Genes / Genética / Genotipo Límite: Humanos País/Región como asunto: Asia Idioma: Chino Revista: Chinese Journal of Preventive Medicine Año: 2006 Tipo del documento: Artículo