First successful preimplantation genetic diagnosis in Singapore--avoidance of beta-thalassaemia major
Annals of the Academy of Medicine, Singapore
;
: 720-723, 2009.
Artículo
en Inglés
| WPRIM
| ID: wpr-290326
ABSTRACT
<p><b>INTRODUCTION</b>We report on the first successful preimplantation genetic diagnosis (PGD) in Singapore.</p><p><b>CLINICAL PICTURE</b>A couple who are beta-thalassaemia carriers and have an affected daughter requested for PGD.</p><p><b>TREATMENT</b>Two cycles of PGD were performed on the couple. Beta-thalassaemia mutations were detected using a nested PCR and minisequencing strategy, and unaffected embryos were selected for transfer.</p><p><b>OUTCOME</b>A singleton pregnancy was achieved in the second PGD cycle, resulting in the birth of a healthy baby boy with carrier genotype.</p><p><b>CONCLUSIONS</b>This case report documents the first successful PGD in Singapore, involving a couple at-risk of transmitting beta-thalassaemia major.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Singapur
/
Fertilización In Vitro
/
Factores de Riesgo
/
Talasemia beta
/
Diagnóstico Preimplantación
/
Diagnóstico
/
Genética
Tipo de estudio:
Estudio diagnóstico
/
Estudio de etiología
/
Factores de riesgo
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
/
Embarazo
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Annals of the Academy of Medicine, Singapore
Año:
2009
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS