Protective effect of GSH on PD model induced by 6-OHDA in vitro / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences)
;
(6): 355-358, 2002.
Artículo
en Inglés
| WPRIM
| ID: wpr-290513
ABSTRACT
To study the effects of 6-hydroxydopamine (6-OHDA) and reduced glutathione (GSH) on the nigral dopaminergic neurons in brain slices in vitro, immolunohistochemical technique was used to observe the changes of TH-stained neurons, including cell bodies and the dendrites, in the substantia nigra (SN) of midbrain slices of rats after incubation for 1 h in the presence of GSH 15 min before and during the period of incubation with 6-OHDA. The results showed that cell bodies remained intact but dendrites were fragmented and truncated after treatment with 6-OHDA. The antioxidant GSH alone did not significantly affect the dendrites of SN neurons but prevented 6-O-HDA-induced damage of dendrites. It was concluded that glutathione may prevent 6-OHDA-induced dopaminergic neurodegeneration and play a protective role in dopaminergic neurons.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Enfermedad de Parkinson Secundaria
/
Patología
/
Tirosina 3-Monooxigenasa
/
Sustancia Negra
/
Distribución Aleatoria
/
Oxidopamina
/
Ratas Sprague-Dawley
/
Usos Terapéuticos
/
Quimioterapia
/
Glutatión
Límite:
Animales
Idioma:
Inglés
Revista:
Journal of Huazhong University of Science and Technology (Medical Sciences)
Año:
2002
Tipo del documento:
Artículo
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