Efficacy of Vancomycin-beta-lactam Combinations Against Heterogeneously Vancomycin-Resistant Staphylococcus aureus (hetero-VRSA)
Journal of Korean Medical Science
; : 319-324, 2003.
Article
en En
| WPRIM
| ID: wpr-29062
Biblioteca responsable:
WPRO
ABSTRACT
There have been conflicting data about the interactions between vancomycin and beta-lactam agents against Staphylococcus aureus strains with heterogeneous resistance to vancomycin. We evaluated the efficacy of these combinations against Mu 3 and heterogeneously vancomycin-resistant S. aureus (hetero-VRSA) strains which were isolated from Korean patients using a population analysis method. Antagonistic effects were observed when less than 1 g/mL of beta-lactam antibiotics was combined with vancomycin, whereas synergistic effects were noticed with more than 4 microgram/mL of beta-lactam antibiotics. The antagonistic effects at low concentrations of beta-lactams were most prominent at 2 microgram/mL of vancomycin, which were the vancomycin MICs of tested hetero-VRSA strains. This study showed the variable effects of vancomycin- beta-lactam combinations depending on the concentrations of beta-lactam antibiotics and this property could be used to develop screening methods for hetero-VRSA strains.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Oxacilina
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Staphylococcus aureus
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Técnicas In Vitro
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Vancomicina
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Pruebas de Sensibilidad Microbiana
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Cefotaxima
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Resistencia betalactámica
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Resistencia a la Vancomicina
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Sinergismo Farmacológico
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Antibacterianos
Límite:
Humans
Idioma:
En
Revista:
Journal of Korean Medical Science
Año:
2003
Tipo del documento:
Article