Effect of arginine vasopressin on membrane potential of dorsal root ganglion neurons in rats / 生理学报
Acta Physiologica Sinica
;
(6): 107-111, 2004.
Artículo
en Chino
| WPRIM
| ID: wpr-290880
ABSTRACT
The effect of arginine vasopressin (AVP) on membrane potential of neurons from dorsal root ganglion (DRG) was examined in the rat by means of intracellular recording technique. The results showed that (1) AVP induced hyperpolarization in the membrane of most DRG neurons. (2) The membrane conductance of the DRG neurons increased by 19.32% following application of AVP (p<0.05). (3) Perfusion with balance sodium solution (BSS) containing Cd(2+) (blocker of Ca(2+) channel) instead of Na+ failed to affect the AVP-induced membrane hyperpolarization of the DRG neurons (p> 0.05). After perfusion with BSS containing tetraethylammonium (TEA), however, the extent of AVP-induced hyperpolarization was reduced (p<0.05). (4) The AVP-induced hyperpolarization of the neurons was blocked by the antagonist of AVP V(1) receptors. The results demonstrate that AVP induces hyperpolarization of most DRG neurons, which might be caused by K(+) outflow mediated by AVP V(1) receptors in the membrane of the neurons.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Fisiología
/
Arginina Vasopresina
/
Canales de Potasio
/
Técnicas de Placa-Clamp
/
Tetraetilamonio
/
Bloqueadores de los Canales de Potasio
/
Ganglios Espinales
/
Potenciales de la Membrana
/
Neuronas
Límite:
Animales
Idioma:
Chino
Revista:
Acta Physiologica Sinica
Año:
2004
Tipo del documento:
Artículo
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