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Relationship between hippocampal long term potentiation induction and activity of 26S proteasome / 生理学报
Acta Physiologica Sinica ; (6): 648-652, 2003.
Artículo en Chino | WPRIM | ID: wpr-290913
ABSTRACT
The present study examined the changes in 26S proteasome activity and the signal molecule mechanism regulating 26S proteasome activity in long term potentiation (LTP) in rat hippocampal slices. The results are as follows 26S proteasome activity was 190+/-14.3 cpm/(100 microg.2 h) before tetanus, a significant increase in 26S proteasome activity (273+/-18.3 cpm/(100 microg.2 h) was found 10 min after tetanus, when the slope of fEPSP was markedly increased. Interestingly, 26S proteasome activity returned to baseline level (210+/-12.8 cpm/(100 microg.2 h) 60 min after tetanus. Moreover, the N-methyl-D-aspartate (NMDA) receptor inhibitor AP-5, which blocked LTP, prevented the increase in the 26S proteasome activity. The results suggest that NMDA receptors contribute to the transient increase in 26S proteasome activity during induction of LTP in the hippocampal CA1 region.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Péptido Hidrolasas / Fisiología / Receptores de N-Metil-D-Aspartato / Potenciación a Largo Plazo / Complejo de la Endopetidasa Proteasomal / Hipocampo / Metabolismo Límite: Animales Idioma: Chino Revista: Acta Physiologica Sinica Año: 2003 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Péptido Hidrolasas / Fisiología / Receptores de N-Metil-D-Aspartato / Potenciación a Largo Plazo / Complejo de la Endopetidasa Proteasomal / Hipocampo / Metabolismo Límite: Animales Idioma: Chino Revista: Acta Physiologica Sinica Año: 2003 Tipo del documento: Artículo