Cell origin of localized Castleman's disease of hyaline-vascular type / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 397-400, 2004.
Artículo
en Chino
| WPRIM
| ID: wpr-291408
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the cell features of 6 Castleman's disease patients and evaluate their prognosis.</p><p><b>METHODS</b>The resected tumors were investigated by routine histopathology and immunohistochemistry. Reverse-transcript PCR (RT-PCR) and sequencing of RT-PCR products were used to assess the clonal characters of the main tumor cells.</p><p><b>RESULTS</b>Histologically, all of the 6 tumors were classified as the hyaline vascular type. B-cells dominated the follicular germinal centers, with T-cells dispersing inter-follicularly. The results of RT-PCR each obtained a single band of either 128 bp or 122 bp and sequencing showed that there was highly homogeneity within the same length sequences, accompanied by fewer different nucleotide acids.</p><p><b>CONCLUSION</b>Monoclonal and/or oligoclonal B cells were identified in Castleman's disease. These B cells were originated from germinal center cells.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Pronóstico
/
Inmunohistoquímica
/
Linfocitos B
/
Reordenamiento Génico de Cadena Pesada de Linfocito B
/
Enfermedad de Castleman
/
Células Clonales
/
Antígenos Comunes de Leucocito
/
Antígenos CD20
/
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
Tipo de estudio:
Estudio pronóstico
Límite:
Adolescente
/
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Hematology
Año:
2004
Tipo del documento:
Artículo
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