The effect of inhalable titanium dioxide on the oxidative stress among occupational population / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 775-779, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-291479
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the inhalable titanium dioxide exposure level and make an assessment of its oxidative effect on occupational exposed population.</p><p><b>METHODS</b>A total of 7 workers occupationally exposing to inhalable titanium dioxide were recruited into the study. The basic information and occupational history were collected by interview, while their blood sample (10 ml for each subject) were collected before and after the investigation, respectively. Pre- and post-work shift urine samples (60 ml for each subject) were collected for 29 days consecutively. The daily personal titanium dioxide exposure level, temperature and relative humidity were detected too. Urinary 8-hydroxy-deoxyguanosine (8-OHdG) and serum high-sensitivity C-reactive protein (hs-CRP) were detected by ELISA and latex immunoturbidimetric assay, respectively.</p><p><b>RESULTS</b>The mean concentration of air inhalable titanium dioxide was (1.194 ± 1.015) mg/m(3). Serum hs-CRP level before and after the investigation was (1.13 ± 1.08), (1.33 ± 1.01) mg/L, respectively. No statistical significance was observed between hs-CRP level before and after the investigation (t = -0.848, P = 0.425). Pre- and post-work shift urinary 8-OHdG was (3.51 ± 1.39), (3.65 ± 1.06) µmol/mol Cr, respectively. A positive correlation was found between the concentration of inhalable titanium dioxide and the changes of 8-OHdG level (r = 0.192, t = 2.09, P = 0.039). Linear mixed-effect models, adjusted by work shift, years of employment, age, body mass index, smoking status, temperature and relative humidity, showed no significant exposure-respond trend between the inhalable titanium dioxide concentration and 8-OHdG level (β = 0.288, t = 1.940, P = 0.055).</p><p><b>CONCLUSION</b>Our findings do not support the potential link between occupationally exposure to inhalable titanium dioxide and high induction of DNA oxidative stress.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Titanio
/
Orina
/
Sangre
/
Proteína C-Reactiva
/
Exposición Profesional
/
Estrés Oxidativo
/
Desoxiguanosina
/
Contaminantes Ocupacionales del Aire
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Preventive Medicine
Año:
2010
Tipo del documento:
Artículo
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