A Meta analysis: mother to infant transmission of hepatitis B virus via different combined immunoprophylaxis delivery modes / 中华预防医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the effect of different combined immunoprophylaxis delivery modes on mother to infant transmission of hepatitis B virus (HBV).</p><p><b>METHODS</b>Six hundred and ninety-six relevant literatures were collected by systematic literature search. Meta-analysis was applied to seven selected literatures that met the criteria and to assess the influence on the infant HBV transmission via different delivery patterns by infants combined immunoprophylaxis.</p><p><b>RESULTS</b>A total of 1435 cases from seven studies which met the criteria were included. The positive rate of HBV was 7.34% (61/831) among the 831 infants in the vaginal delivery group and 4.80% (29/604) among the 604 infants in the caesarean section group. There was no statistically difference between the two groups (OR = 0.70, 95%CI 0.45 - 1.11, Z = 1.52, P = 0.13).</p><p><b>CONCLUSION</b>There was no significant effect of delivery modes on infant infectious rate of HBV by infants' passive and active immunization.</p>