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A nested case-control study on the relationship of three kinds of cytokines and risk of cardio-cerebrovascular events among Inner Mongolians / 中华预防医学杂志
Zhonghua Yu Fang Yi Xue Za Zhi ; (12): 254-258, 2015.
Article en Zh | WPRIM | ID: wpr-291605
Biblioteca responsable: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between homocysteine (Hcy), von willebrand factor (vWF), soluble intercellular adhesion molecule-1 (sICAM-1) and the risk of cardio-cerebrovascular events among Inner Mongolians.</p><p><b>METHODS</b>A survey was conducted among 2 589 Inner Mongolians from May 2002 to June 2003, and they were followed up for about ten years. The 182 individuals who developed cardio-cerebrovascular events in the cohort were defined as cases and those whose age, gender and residence 1:1 matched to cases were selected from the individuals who did not developed cardio-cerebrovascular events as controls. Then, a nested case-control study was used to analyze the relationship between Hcy, vWF and sICAM-1 and risk of cardio-cerebrovascular events. Conditonallogistic regression analysis was used to calculate OR values and 95% CI.</p><p><b>RESULTS</b>The cases had a higher baseline blood pressure, higher prevalence of hypertension and family history of hypertension compared to controls (all P values < 0.05), however, there were no significantly different between TC, TG, LDL-C, HDL-C, FBG, smoking and drinking rates (all P values > 0.05). The M (P(25)-P(75)) of Hcy were 10.68 (7.84-14.98) and 10.02 (6.64-13.94) µmol/L, vWFs were 10.88 (8.14-14.58) and 10.42 (7.97-13.50) mg/L, sICAM-1 were 336.48 (260.68-409.87) and 335.12 (269.87-409.87) ng/ml. They were not significantly different between the two groups (Z values were 0.89, 0.94 and 0.29, respectively, all P values >0.05). After adjustment for the family history of hypertension, hypertension, TC, FPG, BMI, smoking and drinking rate, the conditional logistic regression showed that OR (95% CI) of risk of cardio-cerebrovascular events were 1.00 (0.52-1.93), 2.37 (1.25-4.49), and 0.81 (0.45-1.47) for the participants with increased Hcy, vWF, and sICAM-1, compared with those with normal Hcy, vWF, and sICAM-1, respectively.</p><p><b>CONCLUSION</b>In the Inner Mongolians, increased vWF at baseline may increase the risk of cardio-cerebrovascular events, and increased Hcy and sICAM-1 were not significantly associated with the risk of cardio-cerebrovascular events.</p>
Asunto(s)
Texto completo: 1 Índice: WPRIM Asunto principal: Factor de von Willebrand / Enfermedades Cardiovasculares / Estudios de Casos y Controles / Modelos Logísticos / Riesgo / Prevalencia / Factores de Riesgo / Citocinas / Molécula 1 de Adhesión Intercelular / Accidente Cerebrovascular Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: Zh Revista: Zhonghua Yu Fang Yi Xue Za Zhi Año: 2015 Tipo del documento: Article
Texto completo: 1 Índice: WPRIM Asunto principal: Factor de von Willebrand / Enfermedades Cardiovasculares / Estudios de Casos y Controles / Modelos Logísticos / Riesgo / Prevalencia / Factores de Riesgo / Citocinas / Molécula 1 de Adhesión Intercelular / Accidente Cerebrovascular Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: Zh Revista: Zhonghua Yu Fang Yi Xue Za Zhi Año: 2015 Tipo del documento: Article