Association of programmed cell death 1 gene polymorphisms with dilated cardiomyopathy in Chinese Han population / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 362-366, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-291771
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between programmed death 1 (PDCD1) gene polymorphism and dilated cardiomyopathy (DCM).</p><p><b>METHODS</b>Two single nucleotide polymorphisms (SNPs) of the PDCD1 gene, rs2227981, rs2227982, were genotyped and detected in 340 DCM patients and 401 healthy controls using the method of polymerase chain reaction-restriction fragment length polymorphism (PCRRFLP). The genotype frequencies and allele frequencies of SNPs were compared between DCM patients and normal controls.</p><p><b>RESULTS</b>The genotype and allele distributions of rs2227982 were significantly different between the patients with DCM and the controls. The frequencies of TT genotype and T allele of rs2227982 were higher in the patients than those in the controls (35.3% vs. 23.4%, P < 0.01, OR=2.37, 95%CI 1.57-3.57; 58.5% vs. 47.4%, P < 0.01, OR=1.58, 95%CI 1.28-1.93, respectively). No association was observed for rs2227981 between the DCM patients and the controls.</p><p><b>CONCLUSION</b>rs2227982 in PDCD1 gene is association with DCM in Chinese Han population, which supported PDCD1 as a susceptibility gene for DCM. TT genotypes and T allele in rs2227982 may be associated with significantly increased risk of DCM.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Datos de Secuencia Molecular
/
Secuencia de Bases
/
Cardiomiopatía Dilatada
/
Estudios de Casos y Controles
/
Predisposición Genética a la Enfermedad
/
Polimorfismo de Nucleótido Simple
/
Pueblo Asiatico
/
Etnología
/
Receptor de Muerte Celular Programada 1
/
Frecuencia de los Genes
Tipo de estudio:
Estudio observacional
/
Factores de riesgo
Límite:
Adolescente
/
Adulto
/
Anciano
/
Aged80
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Medical Genetics
Año:
2014
Tipo del documento:
Artículo
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