A study on the factors influencing insulin resistance in children and adolescents / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 234-236, 2004.
Artículo
en Chino
| WPRIM
| ID: wpr-291781
ABSTRACT
<p><b>OBJECTIVE</b>To explore the factors influencing insulin resistance in children with different nutritional status during pubertal development.</p><p><b>METHODS</b>Three hundred children with simple obese aged 7 to 17 years, and 300 normal healthy children and 300 children with malnutrition, matched for age (+/- 3 months) and height (+/- 2 cm), were selected. Fasting serum levels of leptin, insulin, glucose, total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C) and high density lipoprotein-cholesterol (HDL-C) were measured for them.</p><p><b>RESULTS</b>Levels of fasting serum insulin in obese children, except for boys at Tanner stage I and girls at Tanner stage II, were higher than those in normal and malnutrition children (P < 0.01). Average serum level of leptin in obese boys and girls at varied Tanner stages was higher than that in normal children, and higher in normal children than that in children with malnutrition (P<0.01). Serum level of TG in obese children [(1.53 +/- 0.13) mmol/L] was higher than that in normal ones [(1.12 +/- 0.10) mmol/L] and in children with malnutrition [(1.03 +/- 0.09) mmol/L]. There was no significant difference in levels of fasting blood glucose and other blood lipids between the three groups of children. Insulin sensitivity decreased with pubertal development and its index reversely correlated with Tanner stage and serum level of leptin (r=-0.27 and -0.36, respectively, P<0.01).</p><p><b>CONCLUSION</b>Obesity (BMI), serum level of leptin and pubertal development were independent risk factors for insulin resistance in children aged 7 to 17 years.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
Testosterona
/
Sangre
/
Resistencia a la Insulina
/
Hormona del Crecimiento
/
Índice de Masa Corporal
/
Pubertad
/
Leptina
/
Desnutrición
/
Estradiol
Tipo de estudio:
Factores de riesgo
Límite:
Adolescente
/
Niño
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Preventive Medicine
Año:
2004
Tipo del documento:
Artículo
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