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Human foreskin acellular matrix graft: a good scaffold for urethral tissue engineering / 中华男科学杂志
National Journal of Andrology ; (12): 409-412, 2009.
Artículo en Chino | WPRIM | ID: wpr-292362
ABSTRACT
<p><b>OBJECTIVE</b>To provide evidence of using the human foreskin acellular matrix graft for urethral tissue engineering. METH-ODS The human foreskin acellular matrix graft was prepared, its safety and biocompatibility as urethral material were determined by histological observation, cytotoxicity test using primary epithelial cells and experiment in vivo.</p><p><b>RESULTS</b>Intact cells were absent from the foreskin acellular matrix graft. The cytotoxicity test showed that the relative growth rate of the cells was between 75% and 99%, and the cytotoxicity of the foreskin acellular matrix graft was grade 1, consistent with the national standard. With the lengthening of time, the foreskin acellular matrix graft became perfectly compatible with the urothelial cells and the urethral multi-layer structure was restored to normal gradually.</p><p><b>CONCLUSION</b>The human foreskin acellular matrix graft, with its low antigenicity and good biocompatibility, could be a good scaffold for urethral tissue engineering.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Cirugía General / Trasplante / Uretra / Células Cultivadas / Procedimientos de Cirugía Plástica / Biología Celular / Ingeniería de Tejidos / Técnicas de Cultivo de Tejidos / Prepucio / Métodos Límite: Humanos / Masculino Idioma: Chino Revista: National Journal of Andrology Año: 2009 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Cirugía General / Trasplante / Uretra / Células Cultivadas / Procedimientos de Cirugía Plástica / Biología Celular / Ingeniería de Tejidos / Técnicas de Cultivo de Tejidos / Prepucio / Métodos Límite: Humanos / Masculino Idioma: Chino Revista: National Journal of Andrology Año: 2009 Tipo del documento: Artículo