Correlation of prostate cancer susceptibility with genetic polymorphism of cytochrome P450 2E1, smoking and drinking: a case-control study in the population of Nanjing area / 中华男科学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the association of the risk of prostate cancer (PCa) with the polymorphism of the CYP2E1 gene, smoking and drinking, and to explore the joint role of genes and living habits in PCa pathogenesis.</p><p><b>METHODS</b>We conducted a case-control study on 109 PCa patients and 202 age-matched non-PCa male controls, and detected the polymorphisms of CYP2E1 Rsa I and Pst I sites by PCR-RFLP using DNA from peripheral blood lymphocytes.</p><p><b>RESULTS</b>The history of deep smoking (OR = 2.29, 95% CI 1.28 - 4.09) or heavy smoking (OR = 1.81, 95% CI 1.02 - 3.22) was a risk factor. The CYP2E1 C1/C1 genotype significantly increased the risk of PCa (OR = 1.71, 95% CI 1.04 - 2.82) and apparently interacted with drinking (OR = 2.21, 95% CI 1.06 - 4.59). Heavy smokers with the C1/C1 genotype showed an increased risk of PCa (OR = 2.80, 95% CI 1.20 - 6.56), as compared with non-smokers carrying the genotype of C1/C2 or C2/C2.</p><p><b>CONCLUSION</b>The risk of PCa obviously increases in individuals with both the CYP2E1 C1/C1 genotype and the habit of smoking or drinking, and it has a significant positive correlation with the dose of tobacco exposure.</p>