Influence of lymph vascular space invasion on prognosis of patients with early-stage cervical squamous cell carcinoma / 癌症
Chinese Journal of Cancer
;
(12): 425-430, 2010.
Artículo
en Inglés
| WPRIM
| ID: wpr-292567
ABSTRACT
<p><b>BACKGROUND AND OBJECTIVE</b>In the past decade, no remarkable improvement has been made in the 5-year survival of cervical cancer patients. This study was to explore the influence of lymph vascular space invasion (LVSI) on the prognosis of patients with early-stage cervical squamous cell carcinoma.</p><p><b>METHODS</b>A total of 111 eligible patients with FIGO stage IB and IIA cervical squamous cell carcinoma underwent radical hysterectomy and pelvic lymphadenectomy at Sun Yat-sen University Cancer Center between January 1995 and December 2002. The histopathological slides of the 111 patients were reviewed by a senior gynecological pathologist. LVSI, invasion depth, tumor differentiation and lymph node metastasis were evaluated.</p><p><b>RESULTS</b>LVSI was present in 62 patients. The univariate analysis showed that the risk factors of overall survival (OS) included positive LVSI (P = 0.019) and lymph node metastasis (P = 0.002), while the risk factors of progression-free survival (PFS) included LVSI (P = 0.029), lymph node metastasis (P = 0.002), SccAg value (P = 0.018), invasion depth (P = 0.022) and positive surgical margin (P = 0.002). The multivariate analysis showed that lymph node metastasis was the independent prognostic factor of OS (P = 0.015), while lymph node metastasis and positive surgical margin were the independent factors of PFS (P = 0.006, P = 0.006). LVSI was correlated with lymph node metastasis (P = 0.011).</p><p><b>CONCLUSION</b>Whether LVSI is an independent prognostic factor of early-stage cervical squamous cell carcinoma cannot be determined currently while LVSI is a risk factor of metastasis and relapse.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Pelvis
/
Cirugía General
/
Terapéutica
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Carcinoma de Células Escamosas
/
Modelos de Riesgos Proporcionales
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Neoplasias del Cuello Uterino
/
Estudios Retrospectivos
/
Estudios de Seguimiento
/
Quimioterapia Adyuvante
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Chinese Journal of Cancer
Año:
2010
Tipo del documento:
Artículo
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