Anticancer clinical utility of the apurinic/apyrimidinic endonuclease/redox factor-1 (APE/Ref-1) / 癌症
Chinese Journal of Cancer
;
(12): 333-339, 2010.
Artículo
en Inglés
| WPRIM
| ID: wpr-292584
ABSTRACT
Apurinic/apyrimidinic endonuclease/redox factor-1 (APE/Ref-1), as a type of multifunctional protein, plays an essential role in the base excision repair (BER) pathway, which is responsible for the repair of DNA caused by oxidative and alkylation damage. As importantly, APE/Ref-1 also functions as a redox factor maintaining transcription factors in an active reduced state. APE/Ref-1 stimulates the DNA-binding activity of numerous transcription factors that are involved in cancer promotion and progression, such as AP-1 (Fos/Jun), NF-kappaB, HIF-1alpha, p53, and others. Based on the structures and functions of APE1/Ref-1, we will provide an overview of its activities and explore the budding clinical use of this protein as a target in cancer treatment, and propose that APE/Ref-1 has a great potential for application in clinical research.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Oxidación-Reducción
/
Fisiología
/
Lesiones Precancerosas
/
Tolerancia a Radiación
/
Radioterapia
/
Sistemas de Liberación de Medicamentos
/
Apoptosis
/
Resistencia a Antineoplásicos
/
Polimorfismo de Nucleótido Simple
/
ADN-(Sitio Apurínico o Apirimidínico) Liasa
Límite:
Humanos
Idioma:
Inglés
Revista:
Chinese Journal of Cancer
Año:
2010
Tipo del documento:
Artículo
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