Screen for natural benzylisoquinoline alkaloids against tumor / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2684-2688, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-293239
ABSTRACT
<p><b>OBJECTIVE</b>To search for natural benzylisoquinoline alkaloids against tumor.</p><p><b>METHOD</b>In this study, taken DNA as target, a method was developed for screening of natural benzylisoquinoline alkaloids against tumor from traditional Chinese medicine by the use of centrifugal ultrafiltration combined with HPLC technology. The anti-tumor activity for the compounds screened was evaluated in vitro.</p><p><b>RESULT</b>Nine compounds interacted with DNA were discovered and identified from Macleaya cordata, Chelidonium majus, Coptis chinensis, and the proliferation of four types of human solid cancer cell lines was markedly inhibited by these compounds.</p><p><b>CONCLUSION</b>The developed method was considered to be suitable for screening of natural benzylisoquinoline alkaloids against tumor from traditional Chinese medicine.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Medicamentos Herbarios Chinos
/
Química
/
Papaveraceae
/
Chelidonium
/
Coptis
/
Línea Celular Tumoral
/
Bencilisoquinolinas
/
Proliferación Celular
/
Evaluación Preclínica de Medicamentos
Límite:
Humanos
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2011
Tipo del documento:
Artículo
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