Study of the clinical heterogeneity of movement disorder in Parkinson disease / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the clinical heterogeneity of movement disorder in Parkinson's disease (PD).</p><p><b>METHODS</b>Ninety-eight PD patients (68 males and 30 females) were divided into tremor-dominant PD (n=23), mixed subtype PD (n=29) and postural instability and gait disorder (PIGD)-dominant PD (n=46) groups, and the clinical heterogeneity of the movement function of the patients was compared.</p><p><b>RESULTS</b>The initial symptom of tremor-predominant PD was tremor, but patients with PIGD-dominant PD had rigidity and gait disorder as the initial symptoms, commonly compromising the left limb. The amended Hoehn-Yahr stage of tremor-dominant PD was significantly lower than that of the PIGD-dominant PD, while the score of Mini-Mental State Examination (MMSE) was significantly higher in the former. No statistical differences were found in the gender, course of disease and family history between the patients with different subtypes of PD.</p><p><b>CONCLUSION</b>There are significant differences in the initial and typical symptoms between tremor-dominant PD and PIGD-dominant PD.</p>