The Effect of Proton Pump Inhibitor on Healing of Post-esophageal Variceal Ligation Ulcers / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 232-240, 2008.
Artículo
en Coreano
| WPRIM
| ID: wpr-29346
ABSTRACT
BACKGROUNE/AIMS:
Esophageal variceal ligation (EVL) is the most preferable method for controling variceal bleeding. However, EVL is associated with complications such as hemorrhage, chest pain, dysphagia, and odynophagia due to post-EVL ulcers in the esophageal mucosa. The aim of this study was to assess the effect of proton pump inhibitor (PPI), pantoprazole on the healing of post-EVL ulcers.METHODS:
Forty seven patients were randomly allocated into PPI group and control group. Patients in PPI group received 40 mg of pantoprazole intravenously for 3 days after EVL, then 40 mg of oral pantoprazole for 11 days consecutively. Control patients received intravenous and oral placebo. Endoscopic examinations were performed twice at 7+/-2 days and 14+/-2 days after EVL respectively. Clinical outcomes include the size of ulcers, symptoms reported by patients; chest pain, dysphagia, and odynophagia.RESULTS:
Forty seven patients completed the 7 days protocol (PPI/control; 25/22), and twenty six patients completed the 14 days protocol (PPI/control; 16/10). Post-EVL ulcers in PPI group were significantly smaller than those in control group (7 days; 98.7 mm2/119.4 mm2, 14 days; 32.3 mm2/43.8 mm2, p0.05). Nineteen patients (PPI/control; 9/10) did not complete the 14 days protocol due to patients' refusal and adverse outcomes, such as hepatic failure and sepsis with bleeding from post-EVL ulcer occurred in two patients of control group.CONCLUSIONS:
PPI treatment following EVL may be effective in healing post-EVL ulcer.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Úlcera
/
Várices Esofágicas y Gástricas
/
Análisis de Regresión
/
Esofagoscopía
/
Perfil de Impacto de Enfermedad
/
2-Piridinilmetilsulfinilbencimidazoles
/
Inhibidores de la Bomba de Protones
/
Hemorragia Gastrointestinal
/
Ligadura
/
Antiulcerosos
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio diagnóstico
/
Guía de Práctica Clínica
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
The Korean Journal of Gastroenterology
Año:
2008
Tipo del documento:
Artículo
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