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Neuroprotective effects of Astragulus membranaceus on hypoxia-ischemia brain damage in neonatal rat hippocampus / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 1174-1177, 2003.
Artículo en Chino | WPRIM | ID: wpr-293700
ABSTRACT
<p><b>OBJECTIVE</b>To study neuroprotective effects of astragulus membraneaceus on a neonatal rat hippocampus of hypoxia-ischemia brain damage (HIBD).</p><p><b>METHOD</b>The neonatal hypoxia-ischemia model was established with 7-day-old rat pups. Brain injury was examined by neuron death rate in the hippocampal CA1 area. Caspase-3 (cysteinyl aspartate-specific proteinase) mRNA expression in ipsilateral hippocampal was measured by half-quantitative reverse transcription and polymerization chain reaction (RT-PCR). 90-day-old rats were used in tri-equal-arm maze to observe discrimination learning ability. Sham, model and astragulus-membraneaceus treated groups were set up.</p><p><b>RESULT</b>In model group, caspase-3 mRNA showed an increase at 6h, with maximum arrivimg at 24 h - 48 h after HI. In astragulus-membraneaceus treated group, neurons death rate and caspase-3 mRNA were significantly reduced by astragulus membraneaceus, and discrimination learning ability of developed rats were improved obviously.</p><p><b>CONCLUSION</b>Astragulus membraneaceus has a strong protective effect on neuronal damage in the immature rat hippocampus, which is ralated reducing caspase-3 expression.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Farmacología / ARN Mensajero / Medicamentos Herbarios Chinos / Química / Muerte Celular / Ratas Sprague-Dawley / Apoptosis / Fármacos Neuroprotectores / Caspasas Límite: Animales Idioma: Chino Revista: China Journal of Chinese Materia Medica Año: 2003 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Farmacología / ARN Mensajero / Medicamentos Herbarios Chinos / Química / Muerte Celular / Ratas Sprague-Dawley / Apoptosis / Fármacos Neuroprotectores / Caspasas Límite: Animales Idioma: Chino Revista: China Journal of Chinese Materia Medica Año: 2003 Tipo del documento: Artículo