Effect of GABA on the Contractility of Canine Trachealis Muscle / 영남의대학술지
Yeungnam University Journal of Medicine
;
: 314-322, 1994.
Artículo
en Coreano
| WPRIM
| ID: wpr-29375
ABSTRACT
This study aimed to investigate the existence of GABA receptor and the mechanisms of action of GABA and diazepam of the trachealis muscle isolated from dog. Horizontal muscle strips of 2mm×15mm were prepared from canine trachea, and isometric myography in isolated muscle chamber bubbled with 95/5%-O₂/CO₂ at 36℃, at the pH of 7.4 was performed. Muscle strips contracted responding to the electrical field stimulation (ESP) by 2~20 Hz, 20 msec, monophasic square wave of 60 VDC. GABA and diazepam suppressed the EFS-induced contractions to the similar extent, significantly. (p<0.05). Bicuculline, a GABA(A) receptor antagonist blocked both GABA- and diazepam-inhibitions; but DAVA, a GABA(B) receptor antagoinst did not affect either of them. These results suggest than in the canine trachealis muscle, there may be only GABA(A) receptor, and GABA and diazepam inhibit the contractility via GABA(A) receptor.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Tráquea
/
Bicuculina
/
Receptores de GABA
/
Receptores de GABA-A
/
Diazepam
/
Ácido gamma-Aminobutírico
/
Concentración de Iones de Hidrógeno
/
Miografía
Límite:
Animales
Idioma:
Coreano
Revista:
Yeungnam University Journal of Medicine
Año:
1994
Tipo del documento:
Artículo
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