On-line monitoring of extraction process of danhong injection based on near-infrared spectroscopy / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1657-1662, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-294048
ABSTRACT
<p><b>OBJECTIVE</b>To establish a rapid quantitative analysis method for the quality control of Danhong injection extraction using near-infrared (NIR) spectroscopy.</p><p><b>METHOD</b>Online collecting the NIR spectra during the mixed extraction process of Salvia miltiorrhiza and Carthamus tinctorius, partial least squares regression (PLSR) models were developed for the quality indicators rosmarinic acid (RA), salvia acid B (SaB), lithospermic acid (LA), hydroxysafflor yellow A (HSYA) and solid content (SSC), with HPLC and weight-loss method as reference methods.</p><p><b>RESULT</b>The correlation coefficients of the cross validation for RA, SaB, LA, HSYA and SSC were 0.909 3, 0.915 2, 0.901 9, 0.747 7 and 0.931 4, respectively. And the root mean square errors of cross validation (RMSECV) were 0.012 1, 0.251, 0.017 7, 0.038 1 g x L(-1) and 0.359%, respectively.</p><p><b>CONCLUSION</b>In this study, NIR spectroscopy was successfully applied to achieve the real-time determination of the contents of RA, SaB, LA and SSC, while the performance of the HSYA calibration model needed to be improved.</p>
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Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Estándares de Referencia
/
Sistemas en Línea
/
Medicamentos Herbarios Chinos
/
Química
/
Química Farmacéutica
/
Cromatografía Líquida de Alta Presión
/
Espectroscopía Infrarroja Corta
/
Salvia miltiorrhiza
/
Carthamus tinctorius
/
Métodos
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2013
Tipo del documento:
Artículo
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