Comparative study on toxicity of extracts from Phytolaccae Radix before and after being processed with vinegar / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To extract and separate toxic components from Phytolaccae Radix, and to comare the changes in toxicity of Phytolaccae Radix before and after being processed with vinegar.</p><p><b>METHOD</b>The mucous membrane irritation response, mouse peritoneal inflammation model and in vitro macrophages release NO model were applied to compared the changes in inflammatory toxicity of toxic components from Phytolaccae Radix before and after being processed with vinegar.</p><p><b>RESULT</b>Toxic components of Phytolacca Radix had significant inflammatory toxicity, which could cause conjunctival edema in rabbits, and increase of PGE2 and macrophages release NO content in peritoneal exudate in mice. After being processed with vinegar, they showed reduced irritation, which resulted in decrease of PGE2 and macrophages release NO content in peritoneal exudate in mice.</p><p><b>CONCLUSION</b>After being processed with vinegar, the toxicity of toxic components from Phytolacca Radix decreased obviously.</p>