Identification of chromosomal imbalances in pancreatic carcinoma using comparative genomic hybridization / 中华医学杂志(英文版)

ABSTRACT

<p><b>OBJECTIVE</b>To identify genetic abnormalities in primary pancreatic carcinoma in humans.</p><p><b>METHODS</b>Comparative genomic hybridization (CGH) was used to investigate genomic imbalances in 27 cases of pancreatic carcinomas. Multiple deletions and gains were observed in all tumor specimens.</p><p><b>RESULTS</b>Losses affecting chromosomes 9p, 17p, 4q and 6p and gains involving 8q, 7q, 3q and 1q were commonly observed.</p><p><b>CONCLUSIONS</b>There are multiple regions of chromosomes with changes copy number in pancreatic carcinoma. The altered chromosomal regions may contain several candidate genes which are involved in the development and progress of pancreatic carcinogenesis.</p>