Rapid loss of both CD4+ and CD8+ T lymphocyte subsets during the acute phase of severe acute respiratory syndrome / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 985-987, 2003.
Artículo
en Inglés
| WPRIM
| ID: wpr-294187
ABSTRACT
<p><b>OBJECTIVE</b>To study the alteration of peripheral lymphocyte subsets in severe acute respiratory syndrome (SARS) patients and to help improve the early diagnosis of the disease.</p><p><b>METHODS</b>Anti-coagulating blood samples from 98 SARS patients in the acute phase, 56 normal healthy blood donors, and from patients infected by HIV, CMV and EBV were collected. The T lymphocyte subsets were counted by flow cytometry using fluorescence-labeled specific monoclonal antibodies.</p><p><b>RESULTS</b>A significant decrease was observed in all SARS patients in their peripheral CD4(+) and CD8(+) T lymphocyte absolute counts [256 (104) x 10(6)/L and 256 (117) x 10(6)/L, respectively], which were also lower than those of the patients infected with HIV, CMV and EBV. All patients infected with HIV, CMV and EBV had significantly higher CD8(+) T lymphocyte counts in comparison with normal controls.</p><p><b>CONCLUSIONS</b>Decrease of both CD4(+) and CD8(+) T lymphocytes of patients is related to onset of SARS. T lymphocyte subset analysis would help improve the early diagnosis of the disease.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Linfocitos T CD4-Positivos
/
Linfocitos T CD8-positivos
/
Biología Celular
/
Síndrome Respiratorio Agudo Grave
/
Diagnóstico
/
Recuento de Leucocitos
Tipo de estudio:
Estudio diagnóstico
/
Estudio de tamizaje
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Chinese Medical Journal
Año:
2003
Tipo del documento:
Artículo
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