Study on the association between estrogen receptor-alpha gene polymorphisms and pubertal skeletal developmental status in China / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 540-543, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-294289
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between estrogen receptor-alpha (ER-alpha) gene polymorphisms, pubertal bone mineral density (BMD) and bone turnover markers, to better understand the frequencies of ER-a genotypes.</p><p><b>METHODS</b>The ER-alpha Pvu II and Xba I genotypes were determined by PCR-RFLP in 158 healthy adolescent girls (12-14 years old) while BMD was measured by dual-energy X-ray absorptiometry (DEXA). The bone turnover markers (BAP, BGP, TRACP) and calcium adjust hormone (25-OH-VitD, E2) were detected by ELISA. The relationship among BMD, bone turnover markers, and polymorphisms of ER-a were examined.</p><p><b>RESULTS</b>(1) Although the bone turnover markers had a trend in ER-alpha Pvu II genotypes as pp>PP>Pp but no significant difference was found (P > 0.05). There were no significant differences found among Xba I genotypes and between Px haplotype and non-Px haplotype. (2) No association was noticed between ER-a genotype and BMD at any site of the forearm and the whole body. Compared with non-Px haplotype, the Px haplotype had lower BMD, but there was no significant difference noticed (P > 0.05).</p><p><b>CONCLUSION</b>ER-alpha gene Pvu II and Xba I polymorphism seemed not potentially influence on BMD and bone turnover markers in the pubertal girls in Beijing, suggesting that it might not be the major genetic factor regarding this population.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
Polimorfismo Genético
/
Fosfatasa Ácida
/
Vitamina D
/
Sangre
/
Desarrollo Óseo
/
Haplotipos
/
Polimorfismo de Longitud del Fragmento de Restricción
/
Ensayo de Inmunoadsorción Enzimática
/
Absorciometría de Fotón
Límite:
Adolescente
/
Niño
/
Femenino
/
Humanos
País/Región como asunto:
Asia
Idioma:
Chino
Revista:
Chinese Journal of Epidemiology
Año:
2007
Tipo del documento:
Artículo
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