Potential of vesicular stomatitis virus as an oncolytic therapy for recurrent and drug-resistant ovarian cancer / 癌症
Chinese Journal of Cancer
;
(12): 805-814, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-294456
ABSTRACT
In the last decade, we have gained significant understanding of the mechanism by which vesicular stomatitis virus (VSV) specifically kills cancer cells. Dysregulation of translation and defective innate immunity are both thought to contribute to VSV oncolysis. Safety and efficacy are important objectives to consider in evaluating VSV as a therapy for malignant disease. Ongoing efforts may enable VSV virotherapy to be considered in the near future to treat drug-resistant ovarian cancer when other options have been exhausted. In this article, we review the development of VSV as a potential therapeutic approach for recurrent or drug-resistant ovarian cancer.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neoplasias Ováricas
/
Patología
/
Farmacología
/
Fisiología
/
Terapéutica
/
Virología
/
Replicación Viral
/
Apoptosis
/
Virus de la Estomatitis Vesicular Indiana
/
Resistencia a Antineoplásicos
Límite:
Animales
/
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Chinese Journal of Cancer
Año:
2011
Tipo del documento:
Artículo
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