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Water-filled balloon in the postoperative resection cavity improves dose distribution to target volumes in radiotherapy of maxillary sinus carcinoma / 癌症
Chinese Journal of Cancer ; (12): 786-793, 2011.
Artículo en Inglés | WPRIM | ID: wpr-294464
ABSTRACT
Postoperative radiotherapy is a major treatment for patients with maxillary sinus carcinoma. However, the irregular resection cavity poses a technical difficulty for this treatment, causing uneven dose distribution to target volumes. In this study, we evaluated the dose distribution to target volumes and normal tissues in postoperative intensity-modulated radiotherapy (IMRT) after placing a water-filled balloon into the resection cavity. Three postoperative patients with advanced maxillary sinus carcinoma were selected in this trial. Water-filled balloons and supporting dental stents were fabricated according to the size of the maxillary resection cavity. Simulation CT scans were performed with or without water-filled balloons, IMRT treatment plans were established, and dose distribution to target volumes and organs at risk were evaluated. Compared to those in the treatment plan without balloons, the dose (D98) delivered to 98% of the gross tumor volume (GTV) increased by 2.1 Gy (P = 0.009), homogeneity index (HI) improved by 2.3% (P = 0.001), and target volume conformity index (TCI) of 68 Gy increased by 18.5% (P = 0.011) in the plan with balloons. Dosimetry endpoints of normal tissues around target regions in both plans were not significantly different (P > 0.05) except for the optic chiasm. In the plan without balloons, 68 Gy high-dose regions did not entirely cover target volumes in the ethmoid sinus, posteromedial wall of the maxillary sinus, or surgical margin of the hard palate. In contrast, 68 Gy high-dose regions entirely covered the GTV in the plan with balloons. These results suggest that placing a water-filled balloon in the resection cavity for postoperative IMRT of maxillary sinus carcinoma can reduce low-dose regions and markedly and simultaneously increase dose homogeneity and conformity of target volumes.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Periodo Posoperatorio / Radioterapia / Dosificación Radioterapéutica / Cirugía General / Planificación de la Radioterapia Asistida por Computador / Neoplasias del Seno Maxilar / Diagnóstico por Imagen / Carcinoma de Células Escamosas / Tomografía Computarizada por Rayos X / Stents Tipo de estudio: Estudio diagnóstico Límite: Adulto / Anciano / Femenino / Humanos / Masculino Idioma: Inglés Revista: Chinese Journal of Cancer Año: 2011 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Periodo Posoperatorio / Radioterapia / Dosificación Radioterapéutica / Cirugía General / Planificación de la Radioterapia Asistida por Computador / Neoplasias del Seno Maxilar / Diagnóstico por Imagen / Carcinoma de Células Escamosas / Tomografía Computarizada por Rayos X / Stents Tipo de estudio: Estudio diagnóstico Límite: Adulto / Anciano / Femenino / Humanos / Masculino Idioma: Inglés Revista: Chinese Journal of Cancer Año: 2011 Tipo del documento: Artículo