A new method of designing genechip probe for frontier port detection of pathogenic microorganism / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 643-652, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-294601
ABSTRACT
In the process of designing genechip probe for detecting pathogenic microorganism, the selection of single nucleotide polymorphism (SNP) combination is of great importance. At present, there is no automatic design method. This work is hard and the result is not always well. A new approach for selecting SNP combination is presented in this paper. Genetic algorithm is used to search optimal solution on the basis of classification ability of SNP combination, which is evaluated by the rough set theory. Other related experimental parameters are also incorporated. Experimental results show that the method can find out the best SNP combination pattern efficiently and accurately, thus demonstrating the reliability of this new method for designing the genechip probe.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Algoritmos
/
Brucella
/
Datos de Secuencia Molecular
/
Secuencia de Bases
/
Salmonella enterica
/
Análisis de Secuencia por Matrices de Oligonucleótidos
/
Polimorfismo de Nucleótido Simple
/
Métodos
Tipo de estudio:
Estudio diagnóstico
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Biomedical Engineering
Año:
2009
Tipo del documento:
Artículo
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