The influence of zoledronic acid on vascular endothelial cell / 中华口腔医学杂志
Chinese Journal of Stomatology
;
(12): 399-402, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-294695
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the influence of zoledronic acid on vascular endothelial cells.</p><p><b>METHODS</b>The influence of zoledronic acid on proliferation, migration and adhesion of vascular endothelial cells were tested with 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), cell migration assay and cell adhesion assay. The results of each experimental group were compared with the control group and the data statistically analyzed.</p><p><b>RESULTS</b>In a concentration of 0-0.5 mmol/L, the absorbance value decreased from 0.09 to 0.34 as the drug concentration increased. Scratch test showed that the change of width of scratch before and after 24 hours in control, low, medium and high concentration groups were (38.7 ± 0.42), (35.8 ± 4.17), (19.9 ± 0.57) mm (P < 0.001), (12.5 ± 3.89) mm (P < 0.05). Adhesion test showed that the absorbance value in control, low, medium and high concentration groups were 1.14 ± 0.18, 0.95 ± 0.13, 0.81 ± 0.11 (P < 0.01), 0.67 ± 0.19 (P < 0.001). Comparisons between control and experimental groups were analyzed by t-test and P values < 0.05 were considered statistically significant.</p><p><b>CONCLUSIONS</b>Zoledronic acid inhibits the proliferation, migration and adhesion of vascular endothelial cells.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Fisiología
/
Farmacocinética
/
Adhesión Celular
/
Movimiento Celular
/
Biología Celular
/
Células Endoteliales
/
Proliferación Celular
/
Difosfonatos
/
Imidazoles
Idioma:
Chino
Revista:
Chinese Journal of Stomatology
Año:
2015
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS