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Effects of telmisartan on voltage-gated Kv1.3 and Kv1.5 potassium channels expressed in Xenopus oocytes / 中华心血管病杂志
Chinese Journal of Cardiology ; (12): 165-168, 2009.
Article en Zh | WPRIM | ID: wpr-294755
Biblioteca responsable: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effects of telmisartan on Kv1.3 and Kv1.5 potassium channels expressed in Xenopus oocytes.</p><p><b>METHODS</b>Kv1.3 and Kv1.5 potassium channel currents expressed in Xenopus oocytes were recorded and observed in the absence and presence of telmisartan using standard two-microelectrode voltage clamp techniques.</p><p><b>RESULTS</b>Telmisartan resulted in a concentration- and voltage-dependent inhibition effect on Kv1.3 channel current (IC(50) 2.05 micromol/L)and on Kv1.5 channel current (IC(50) 2.37 micromol/L).</p><p><b>CONCLUSIONS</b>Telmisartan blocks open-state Kv1.3 channel which could be one of the mechanisms related to its immunomodulatory and anti-atherosclerosis effect. Telmisartan also blocks open-state Kv1.5 channel which might partly account for its effect on reducing the incidence of atrial fibrillation.</p>
Asunto(s)
Texto completo: 1 Índice: WPRIM Asunto principal: Oocitos / Farmacología / Xenopus / Bencimidazoles / Benzoatos / Técnicas In Vitro / Técnicas de Placa-Clamp / Metabolismo Límite: Animals Idioma: Zh Revista: Chinese Journal of Cardiology Año: 2009 Tipo del documento: Article
Texto completo: 1 Índice: WPRIM Asunto principal: Oocitos / Farmacología / Xenopus / Bencimidazoles / Benzoatos / Técnicas In Vitro / Técnicas de Placa-Clamp / Metabolismo Límite: Animals Idioma: Zh Revista: Chinese Journal of Cardiology Año: 2009 Tipo del documento: Article