Effects of telmisartan on voltage-gated Kv1.3 and Kv1.5 potassium channels expressed in Xenopus oocytes / 中华心血管病杂志
Chinese Journal of Cardiology
; (12): 165-168, 2009.
Article
en Zh
| WPRIM
| ID: wpr-294755
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effects of telmisartan on Kv1.3 and Kv1.5 potassium channels expressed in Xenopus oocytes.</p><p><b>METHODS</b>Kv1.3 and Kv1.5 potassium channel currents expressed in Xenopus oocytes were recorded and observed in the absence and presence of telmisartan using standard two-microelectrode voltage clamp techniques.</p><p><b>RESULTS</b>Telmisartan resulted in a concentration- and voltage-dependent inhibition effect on Kv1.3 channel current (IC(50) 2.05 micromol/L)and on Kv1.5 channel current (IC(50) 2.37 micromol/L).</p><p><b>CONCLUSIONS</b>Telmisartan blocks open-state Kv1.3 channel which could be one of the mechanisms related to its immunomodulatory and anti-atherosclerosis effect. Telmisartan also blocks open-state Kv1.5 channel which might partly account for its effect on reducing the incidence of atrial fibrillation.</p>
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Oocitos
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Farmacología
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Xenopus
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Bencimidazoles
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Benzoatos
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Técnicas In Vitro
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Técnicas de Placa-Clamp
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Metabolismo
Límite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Cardiology
Año:
2009
Tipo del documento:
Article